Known case of Sjogren's Syndrome with hypothyroidism and hypertension.
Fairly large, symmetrical hyperintensities in periventricular frontal, parietal and parietooccipital white matter regions with similar smaller lesions in brainstem, cerebellum, bilateral thalamic and capsuloganglionic regions.
Possible cause is autoimmune pathology with vascular involvement. Corticosteroid therapy results in rapid and nearly complete resolution of the cortical lesions with marked improvement of the clinical manifestations. Memory disturbance is a rare initial manifestation in meningoencephalitis associated with SjS.
Ref: Journal of the Neurological Sciences, Volume 232, Issue 1-2, Pages 111-113
Submitted by Dr MGK Murthy (Elbit Medical Diagnostics)
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